Peptide Information

General Information of This Peptide
Peptide ID
BTDP000838
Peptide Name
ChTx-c (E18Q,K19Y,Y21H,K32E)
Symonym
ChTx-c (E18Q,K19Y,Y21H,K32E)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
QFTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS
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Mutant Sequence
QFTNVSCTTSKECWSVCQRLHNTSRGKCMNKECRCYS
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Sequence Length
37
Mass(Da)
4297
Sequence Removed Signal Peptide
QFTNVSCTTSKECWSVCQRLHNTSRGKCMNKECRCYS
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa3.1 Dissociation constant
37 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Dissociation constant
693 nM
 .
Blocker
 [2]
References
Ref 1 Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 1;277(5):3793-800. doi: 10.1074/jbc.M107507200. Epub 2001 Nov 27.
Ref 2 Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels. J Biol Chem. 2000 Jan 14;275(2):1201-8. doi: 10.1074/jbc.275.2.1201.
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