Peptide Information

General Information of This Peptide
Peptide ID
BTDP000570
Peptide Name
Potassium channel toxin ShK ([pTyr][AEEA],M21[Nle])
Symonym
Potassium channel toxin ShK ([pTyr][AEEA],M21[Nle])
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
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Mutant Sequence
[pTyr][AEEA]RSCIDTIPKSRCTAFQCKHS[Nle]KYRLSFCRKTCGTC
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Sequence Length
37
Mass(Da)
4424
Sequence Removed Signal Peptide
[pTyr][AEEA]RSCIDTIPKSRCTAFQCKHS[Nle]KYRLSFCRKTCGTC
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Disulfide Bond
5-30;14-34;19-37
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 IC50
0.109 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 IC50
2.2 nM
 .
Blocker
 [1]
References
Ref 1 Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes. Mol Pharmacol. 2009 Apr;75(4):762-73. doi: 10.1124/mol.108.052704. Epub 2009 Jan 2.
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