Peptide Information

General Information of This Peptide
Peptide ID
BTDP000566
Peptide Name
Potassium channel toxin ShK ([Pmp2Et]D[AEEA])
Symonym
Potassium channel toxin ShK ([Pmp2Et]D[AEEA])
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
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Mutant Sequence
[Pmp2Et]D[AEEA]RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
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Sequence Length
38
Mass(Da)
4612
Sequence Removed Signal Peptide
[Pmp2Et]D[AEEA]RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
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Disulfide Bond
5-30;14-34;19-37
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
0.07 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 Dissociation constant
0.166 nM
 .
Blocker
 [1]
References
Ref 1 Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol. 2005 Apr;67(4):1369-81. doi: 10.1124/mol.104.008193. Epub 2005 Jan 21.
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