Peptide Information

General Information of This Peptide
Peptide ID
BTDP000561
Peptide Name
Potassium channel toxin ShK ([Pmp][AEEA],M21[Nle])
Symonym
Potassium channel toxin ShK ([Pmp][AEEA],M21[Nle])
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
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Mutant Sequence
[Pmp][AEEA]RSCIDTIPKSRCTAFKCKHS[Nle]KYRLSFCRKTCGTC
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Sequence Length
37
Mass(Da)
4422
Sequence Removed Signal Peptide
[Pmp][AEEA]RSCIDTIPKSRCTAFKCKHS[Nle]KYRLSFCRKTCGTC
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Disulfide Bond
5-30;14-34;19-37
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 IC50
0.025 nM
 .
Blocker
 [1]
References
Ref 1 Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK. Mar Drugs. 2015 Jan 16;13(1):529-42. doi: 10.3390/md13010529.
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