Peptide Information

General Information of This Peptide
Peptide ID
BTDP000009
Peptide Name
[K27A]gHwTx-IV
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
ECLEIKFACNPSNDQCCKSSKLVCSRKTRWCKYQI
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Mutant Sequence
GCLGIWKACNPSNDQCCKSSKLVCSRATRWCKWQI
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Sequence Length
35
Mass(Da)
3975
Sequence Removed Signal Peptide
GCLGIWKACNPSNDQCCKSSKLVCSRATRWCKWQI
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Disulfide Bond
2-17;9-24;16-31
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.1 IC50
8.5 ± 2.0 nM
 . . [1]
References
Ref 1 Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. J Biol Chem. 2020 Apr 10;295(15):5067-5080. doi: 10.1074/jbc.RA119.012281. Epub 2020 Mar 5.
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